Modification of Disodium Cromoglycate Passage Across Lung Epithelium In Vitro Via Incorporation into Polymeric Microparticles
نویسندگان
چکیده
منابع مشابه
Disodium cromoglycate can inhibit virus-induced cytopathic effects in vitro.
Investigations showed: haemoglobin 12 8 g/dl; white cell count 11 3 x 109!l (11 300/mm3), with 15 % eosinophils; blood urea 10-3 mmol/I (62 mg/ 100 ml); blood glucose 5-4 mmol/l (98 mg/100 ml); and serum sodium 129 mmol(mEq)/l, potassium 5-2 mmol(mEq)/l, and chloride 97 mmol (mEq)/l. Chest and abdominal x-ray pictures were normal. Antinuclear factor and thyroid and parietal cell antibodies were...
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Rats kept in 10% O2 for three or more weeks developed mast cell hyperplasia in the lungs, especially round the alveoli and the small peripheral blood vessels, which became thickened during chronic hypoxia. There was a significant correlation between the degree of right ventricular hypertrophy (RVH) and the numbers of alveolar and small vessel mast cells. However, mast cell hyperplasia developed...
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Disodium cromoglycate (I; DSCG) was introduced in 1968 for the treatment of bronchial asthma. Evidence concerning its principal effects and possible mode of action has been described at some length in the recent literature (Cox, 1971 ; Cox & Altoanyan, 1970). Crystals of the compound exhibit a remarkable reversible water absorption (Cox, Woodard & McCrone, 1971), the number of water molecules p...
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The effect of topical disodium cromoglycate (DSCG) has been examined in 30 patients with chronic active proctitis using a double-blind crossover trial. Each treatment period was four weeks and patients were given DSCG 200 mg by enema twice daily and 100 mg orally three times each day. Twenty-six patients completed the trial successfully, 14 responded to DSCG treatment, two improved with placebo...
متن کاملDisodium cromoglycate attenuates hypoxia induced enlargement of end-expiratory lung volume in rats.
Mechanism responsible for the enlargement of end-expiratory lung volume (EELV) induced by chronic hypoxia remains unclear. The fact that the increase in EELV persists after return to normoxia suggests involvement of morphological changes. Because hypoxia has been also shown to activate lung mast cells, we speculated that they could play in the mechanism increasing EELV similar role as in vessel...
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ژورنال
عنوان ژورنال: The AAPS Journal
سال: 2011
ISSN: 1550-7416
DOI: 10.1208/s12248-011-9317-2